Last
Susan: "But Grandfather! I belong with you!"
Doctor: "Not any longer, Susan. You're still my grandchild, and always will be. You're a woman too. I want you to belong somewhere, to have roots of your own. With David, you'll be able to find those roots, and live normally like any woman should do. Believe me my dear, your future lies with David, and not with a silly old buffer like me. One day I shall come back...yes, I shall come back. Until then, there must be no regrets, no tears, no anxieties. Just go forward in all your beliefs and prove to me that I'm not mistaken in mine. Goodbye Susan. Goodbye my dear."
The Dalek Invasion of Earth: Flashpoint

Last
Ian: "We do, we still want to go."
Barbara: "Please, Doctor."
Doctor: "Very well, follow me. But you must follow my instructions implicitly, understand? Implicitly! You both have about a fifty-fifty chance. Follow me. Come along."
The Chase: The Planet of Decision

Last
Vicki: "Steven is safe. Katarina will bring him. Come on...we've got to talk."
Doctor (to Vicki & Katarina): "Now you're sure it's just the shoulder, hmm? Right, well, steady, steady. Hold tight, hold on. Yes. Careful. Just a minute. Careful. Careful, Vicki. Oh, dear, dear. This business. There we are. Now, come on, bring him in. Bring him in there. Gently and carefully. That's it, that's it. Put him on the couch."
The Myth Makers: Horse of Destruction

Last
Doctor: "Goodbye Steven, and good luck."
Steven: "Goodbye Doctor."
The Savages: 4

Last
Dodo: "I resist all attempts to change me into somebody else."
Doctor: "Now, I'm going to start counting. And when I've counted up to five, you will be fast asleep. And when you wake again, you will forget all about this distressing incident. Now, I'm going to start counting. Just look at that ring on my hand. One...two...three...four...five."
The War Machines: 2

Last
Doctor: "All right then, off you go! Now go on, Ben can catch his ship and become an Admiral and you Polly, you can look after Ben."
Polly: "I will. You will be safe, won't you?"
The Faceless Ones: 6

Last
Ben: "We might see you sometime. Take care."
Doctor: "Well you'd better hurry. The Commandant's car's waiting."
The Faceless Ones: 6

Last
Doctor: "I won't forget you! Now don't go blundering into too much trouble, will you?">
Jamie: "Oh, you're a fine one to talk!"
The War Games: 10

Last
Victoria: "I'm sorry."
Doctor: "Jamie and I will stay for another day, just in case you want to think again."
Fury from the Deep: 6

Last
Zoe: "Goodbye, Doctor. Will we ever meet again?"
Doctor: "Again? Ah, Zoe, you and I know time is relative, isn't it?"
The War Games: 10

Last
Doctor: "The rubbish tip."
Liz: "Oh, dear!"
Inferno: 7
_{n.b. Probably not the last things the Doctor and Liz said to each other, just the last things we heard.}

Last
Doctor: "Oh, I nearly forgot...your wedding present."
Jo: "It's beautiful. Thank you, Doctor."
The Green Death: 6

Last
Sarah: "You know, travel does broaden the mind!"
Doctor: "Yes. 'Til we meet again, Sarah."
The Hand of Fear: 4

Last
Doctor (to Harry, the Brigadier & Duke of Forgill): "Coming?"
Harry: "I think I'll stick to Inter-City this time, Doctor."
Terror of the Zygons: 4
_{n.b. We never actually witnessed the real Doctor speaking to the real Harry in The Android Invasion.}

Last
Doctor: "Yes?"
Leela: "I will miss you."
The Invasion of Time: 6

Last
Romana: "I'll take care of him."
Doctor: "I'll miss you. You were the noblest Romana of them all!"
Warrior's Gate: 4

Last
Doctor: "Good luck, Adric."
Adric: "'Bye, Doctor."
Earthshock: 4

Last
Nyssa: "I'm fully aware of that, but I want to stay."
Doctor: "You're a very brave person. I wish you luck."
Terminus: 4

Last
Doctor: "No, no...don't leave, not like..."
Tegan: "I must. I'm sorry."
Resurrection of the Daleks: 2

Last
Doctor: "Better to go back while you're a bit of a hero, eh?"
Turlough: "Thank you for everything."
Planet of Fire: 4

Last
Doctor: "I must do what I think is best."
Peri: "I used to think that you were different..that you cared for justice, truth and good. I can barely look at what you are now."
The Trial of a Time Lord: 7

Last
Doctor: "But I don't have an address."
Mel: "Oh, I'll put it in a bottle and throw it into space. It'll reach you...in time."
Dragonfire: 3

Last
Ace: "The Tardis!"
Doctor: "There are worlds out there where the sky is burning, and the sea's asleep, and the rivers dream. People made of smoke and cities made of song. Somewhere there's danger, somewhere there's injustice, somewhere else the tea's getting cold. Come on Ace, we've got work to do."
Survival: 3
_{n.b. Again, not the last things said to each other, merely the last we heard.}

2nd Doctor
First: "Slower...slower. Concentrate on one thing. One thing. It's over. It's over." The Power of the Daleks: 1
Last: "Is this some sort of joke? No! I refuse to be treated in...what're you doing? Stop! You're making me dizzy. No! No! You can't do this to me. No...no...no...no...no...no...no...no...no...no...no...no...no..." The War Games: 10

3rd Doctor
First: "No...no...must find my shoe." Spearhead from Space: 1
Last: "Tears, Sarah-Jane? No, don't cry...while there's life there's..." Planet of the Spiders: 6

4th Doctor
First: "(unintelligable muttering)...I tell you Brigadier, there's nothing to worry about. The brontosaurus is large and placid..." Robot: 1
Last: "It's the end, but the moment has been prepared for." Logopolis: 4

5th Doctor
First: "Tardis...home..." Castrovalva: 1
Last: "Might regenerate...don't know. Feels different this time." The Caves of Androzani: 4

6th Doctor
First: "You were expecting someone else?" The Caves of Androzani: 4
Last: "You know, I think I was rash in turning down that offer of the Presidency. Carrot juice, carrot juice, carrot juice..." The Trial of a Time Lord: 14

7th Doctor
First: "No...no...Mel..." Time and the Rani: 1
Last: "There are worlds out there where the sky is burning, and the sea's asleep, and the rivers dream. People made of smoke and cities made of song. Somewhere there's danger, somewhere there's injustice, somewhere else the tea's getting cold. Come on Ace, we've got work to do." Survival: 3