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<body topmargin=0 leftmargin=0 marginheight=0 marginwidth=0> <table cellpadding=0 cellspacing=0 border=0><tr> <td valign="top" colspan=2 height=22 BGCOLOR="#FFFFFF" TEXT="#080000" bgproperties="fixed" background="041000d2egerdp.gif"> <div> </div> </td> </tr><tr> <td valign="top" width=145 BGCOLOR="#333399" TEXT="#080000" background="040a2c00erkjzj.gif"> <div>  <img src="HTMLobj-414/aniGif.gif" border="0" align="bottom" width="60" height="70">   <img src="HTMLobj-415/aniGif.gif" border="0" align="bottom" width="468" height="60">  </div> </td> <td valign="top" height=458 BGCOLOR="#FFFFFF" TEXT="#080000"> <div> <FONT SIZE="5" COLOR="#336600" FACE="Times New Roman" ><I>NEUROPATHOLOGY</I></FONT><FONT SIZE="1" COLOR="#663399" FACE="Times New Roman" >    </FONT> |    <B> </B><FONT SIZE="2" COLOR="#0000BF" FACE="Times New Roman" ><A HREF="index.htm" TARGET="_top" TITLE="NEUROPATHOLOGY"><U><B>home</B></U></A></FONT></div> <div> <A HREF="id18.htm" TARGET="_top" TITLE="HISTOLOGY REVIEW"><U>HISTOLOGY REVIEW</U></A>   |   <A HREF="id19.htm" TARGET="_top" TITLE="PHYSIOLOGY REVIEW"><U>PHYSIOLOGY REVIEW</U></A>   |   <A HREF="id20.htm" TARGET="_top" TITLE="PATHOLOGY part1"><U>PATHOLOGY part1</U></A>   |   <A HREF="id22.htm" TARGET="_top" TITLE="pathology part2"><U>pathology part2</U></A>   |   <A HREF="id26.htm" TARGET="_top" TITLE="PATHOLOGY3"><U>PATHOLOGY3</U></A>   |   <A HREF="id27.htm" TARGET="_top" TITLE="PATHOLOGY 4"><U>PATHOLOGY 4</U></A>   |   <A HREF="id21.htm" TARGET="_top" TITLE="PICTURES"><U>PICTURES</U></A>   |   <A HREF="id31.htm" TARGET="_top" TITLE="tumor gn"><U>tumor gn</U></A>   |   <A HREF="id30.htm" TARGET="_top" TITLE="multiple sclerosis"><U>multiple sclerosis</U></A>   |   <A HREF="id24.htm" TARGET="_top" TITLE="quiz"><U>quiz</U></A>   |   <A HREF="id23.htm" TARGET="_top" TITLE="quizanswer"><U>quizanswer</U></A>   |   <A HREF="id17.htm" TARGET="_top" TITLE="Contact Me and links"><U>Contact Me and links</U></A>   |   <B>info and news</B></div> <div> <IMG SRC="04207040.gif" border=0 width="263" height="4" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></div> <div> <B>info and news</B></div> <div> Gene Therapy Tested On Alzheimer's </div> <div> Cells Injected Into Patient's Brain May Halt Condition First Use Of Human Gene Therapy To Treat Brain Disease But Complicated Procedure Would Unlikely Reach Millions Of Suffers </div> <bR> <div> SAN DIEGO, April 11, 2001</div> <div> <TABLE BORDER="0" CELLPADDING="1" CELLSPACING="1" WIDTH="188" BORDERCOLORLIGHT="#C0C0C0" BORDERCOLORDARK="#808080" FRAME="VOID" RULES="NONE" ALIGN="BOTTOM" HSPACE="0" VSPACE="0" > <tR> <tD VALIGN=TOP HEIGHT= 16 WIDTH="173"><IMG BORDER="0" SRC="1x1.gif" HEIGHT="16" ALIGN="bottom" WIDTH="173" HSPACE="0" VSPACE="0"></tD> <tD VALIGN=CENTER WIDTH="8"><IMG BORDER="0" SRC="1x1.gif" HEIGHT="16" ALIGN="bottom" WIDTH="8" HSPACE="0" VSPACE="0"></tD> </tR> <tR> <tD VALIGN=TOP HEIGHT= 16 WIDTH="173"><div> AP</div> </tD> <tD VALIGN=CENTER WIDTH="8"><IMG BORDER="0" SRC="1x1.gif" HEIGHT="16" ALIGN="bottom" WIDTH="8" HSPACE="0" VSPACE="0"></tD> </tR> <tR> <tD VALIGN=TOP HEIGHT= 69 WIDTH="173"><div> <B>Human brain showing signs of Alzheimer's dementia in blue area.</B><FONT SIZE="3" COLOR="#000000" FACE="verdana" > </FONT></div> </tD> <tD VALIGN=CENTER ROWSPAN=4 WIDTH="8"><IMG BORDER="0" SRC="1x1.gif" HEIGHT="69" ALIGN="bottom" WIDTH="8" HSPACE="0" VSPACE="0"></tD> </tR> <tR> <tD VALIGN=CENTER HEIGHT= 16 WIDTH="173"><IMG BORDER="0" SRC="1x1.gif" HEIGHT="16" ALIGN="bottom" WIDTH="173" HSPACE="0" VSPACE="0"></tD> </tR> <tR> <tD VALIGN=CENTER BGCOLOR=#C0C0C0 HEIGHT= 16 WIDTH="173"><IMG BORDER="0" SRC="1x1.gif" HEIGHT="16" ALIGN="bottom" WIDTH="173" HSPACE="0" VSPACE="0"></tD> </tR> <tR> <tD VALIGN=CENTER BGCOLOR=#000000 HEIGHT= 16 WIDTH="173"><IMG BORDER="0" SRC="1x1.gif" HEIGHT="16" ALIGN="bottom" WIDTH="173" HSPACE="0" VSPACE="0"></tD> </tR> </TABLE></div> <div> <B>(AP)</B> Neurosurgeons have injected genetically modified cells into the brain of an Alzheimer's patient in a pioneering procedure that may hold the promise of halting or reversing brain cell loss caused by the disease. </div> <bR> <div> The 11-hour procedure at the University of California, San Diego, marked the first use of human gene therapy in the treatment of brain disease, researchers said. </div> <bR> <div> If the procedure works as hoped, improved brain function might be seen in the patient over the next few weeks, but doctors cautioned it would take years to learn if the therapy would benefit Alzheimer's patients in general. </div> <bR> <div> Scientists took skin cells from a 60-year-old Oregon woman in the early stages of Alzheimer's disease and isolated genes that secrete a protein found in healthy brains called nerve growth factor. Two drops of a solution containing those genes were injected into the woman's brain. </div> <bR> <div> She was discharged from the hospital two days later. </div> <bR> <div> "Our hope is that this procedure will be a way of delaying the progress of the disease and improving the quality of life for several years," said Dr. Mark Tuszynski, who led the study. "It's unlikely to be a cure." </div> <bR> <div> The federal government approved human trials for nerve growth factor two years ago after a team of UCSD researchers showed the protein reversed deterioration in the brains of aging monkeys. </div> <bR> <bR> <div> from cbs news</div> <div> Alzheimer's: The Unseen Victims </div> <div> Four Million Americans Suffer From Debilitating Disease But Caregivers Are Also Victims </div> <bR> <div> Dec. 20, 2000</div> <div> <TABLE BORDER="0" CELLPADDING="1" CELLSPACING="1" WIDTH="188" BORDERCOLORLIGHT="#C0C0C0" BORDERCOLORDARK="#808080" FRAME="VOID" RULES="NONE" ALIGN="BOTTOM" HSPACE="0" VSPACE="0" > <tR> <tD VALIGN=TOP HEIGHT= 16 WIDTH="173"><IMG BORDER="0" SRC="1x1.gif" HEIGHT="16" ALIGN="bottom" WIDTH="173" HSPACE="0" VSPACE="0"></tD> <tD VALIGN=CENTER WIDTH="8"><IMG BORDER="0" SRC="1x1.gif" HEIGHT="16" ALIGN="bottom" WIDTH="8" HSPACE="0" VSPACE="0"></tD> </tR> <tR> <tD VALIGN=TOP HEIGHT= 16 WIDTH="173"><div> CBS</div> </tD> <tD VALIGN=CENTER WIDTH="8"><IMG BORDER="0" SRC="1x1.gif" HEIGHT="16" ALIGN="bottom" WIDTH="8" HSPACE="0" VSPACE="0"></tD> </tR> <tR> <tD VALIGN=TOP HEIGHT= 51 WIDTH="173"><div> <B>The Millers, with a grandchild, face Alzheimer's together.</B><FONT SIZE="3" COLOR="#000000" FACE="verdana" > </FONT></div> </tD> <tD VALIGN=CENTER ROWSPAN=4 WIDTH="8"><IMG BORDER="0" SRC="1x1.gif" HEIGHT="51" ALIGN="bottom" WIDTH="8" HSPACE="0" VSPACE="0"></tD> </tR> <tR> <tD VALIGN=CENTER HEIGHT= 16 WIDTH="173"><IMG BORDER="0" SRC="1x1.gif" HEIGHT="16" ALIGN="bottom" WIDTH="173" HSPACE="0" VSPACE="0"></tD> </tR> <tR> <tD VALIGN=CENTER BGCOLOR=#C0C0C0 HEIGHT= 16 WIDTH="173"><IMG BORDER="0" SRC="1x1.gif" HEIGHT="16" ALIGN="bottom" WIDTH="173" HSPACE="0" VSPACE="0"></tD> </tR> <tR> <tD VALIGN=CENTER BGCOLOR=#000000 HEIGHT= 16 WIDTH="173"><IMG BORDER="0" SRC="1x1.gif" HEIGHT="16" ALIGN="bottom" WIDTH="173" HSPACE="0" VSPACE="0"></tD> </tR> </TABLE></div> <div> <B>(CBS)</B> The detrimental effects of Alzheimer's plague not only the sufferers but their loved ones as well. In part three of a special three-part <B>"Eye on America"</B> series, <B>CBS News Medical Correspondent Elizabeth Kaledin</B> reports that the burden for caring for the victim can be as painful as the disease. </div> <bR> <div> When Don Miller was diagnosed with Alzheimer's disease it changed the whole family dynamic. </div> <bR> <div> No longer the confident head of a household, Miller had to give up working, driving, and his independence in the prime of his life. </div> <bR> <div> He says the disease is <B>"a very big burden"</B> in the life of his family, adding that it was <B>"obviously nothing we would have anticipated after we got married or after our careers…but Alzheimer's changes everything…right down to the last nickel it changes things."</B> </div> <bR> <bR> </td> </tr></table></body>